Origins of resistance to toxic agents proceedings of the symposium held in Washington, D. C., March 25-27, 1954 [under the joint auspices of the Office of Naval Research and the University of Pennsylvania] by United States. Office of Naval Research

Cover of: Origins of resistance to toxic agents | United States. Office of Naval Research

Published by Academic Press in New York .

Written in English

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  • Poisons

Edition Notes

Includes bibliographies and indexes

Book details

StatementEditors: M. G. Sevag, Roger D. Reid [and] Orr E. Reynolds
ContributionsSevag, Manasseh Giragos, 1897-, University of Pennsylvania
The Physical Object
Paginationxv, 471 p.
Number of Pages471
ID Numbers
Open LibraryOL16484536M
LC Control Number54011053

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Origins of Resistance to Toxic Agents contains the proceedings of the Symposium held in Washington, D.C. on MarchContributors theoretically explore the origins of drug resistance and related problems, based on the concept that the development of resistance to various toxic agents is associated with alterations and/or loss in enzyme proteins, and can explain the Book Edition: 1.

Origins of Resistance to Toxic Agents contains the proceedings of the Symposium held in Washington, D.C. on MarchContributors theoretically explore the origins of drug resistance and related problems, based on the concept that the development of resistance to various toxic agents is associated with alterations and/or loss in enzyme proteins, and can explain the mutational and other.

Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image Origins of resistance to toxic agents book to browse page by by: 8.

Genre/Form: Electronic books: Additional Physical Format: Print version: Sevag, M. Origins of Resistance to Toxic Agents. Burlington: Elsevier Science, © Origins of Resistance to Toxic Agents: Proceedings of the Symposium Held in Washington, D.C., MarchJAMA.

;(16) doi/jama Origins of resistance to toxic agents. New York, Academic Press, (DLC) (OCoLC) Material Type: Conference publication, Document, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: Manasseh Giragos Sevag; University of Pennsylvania.; United States.

Office of Naval Research. Origins of Resistance to Toxic Agents. Nichol CA. The Yale Journal of Biology and Medicine, 01 Nov28(2): PMCID: PMC Review Free to read & use.

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No abstract provided. Free full text. Yale J. RUSI was pleased to host Dan Kaszeta for a conversation around his latest book Toxic, A History of Nerve Agents, From Nazi Germany to Putin’s Russia., Kaszeta was joined by Dr. Caitriona McLeish for an interactive discussion on the book, and explore what this historical review can teach us about managing chemical weapons risks today.

‘Dan Kaszeta weaves an extraordinary narrative from the secret history of some of the deadliest substances ever created. From the plains of north Germany to the suburbs of Damascus he explains the development and use of nerve agents, employing his own deep knowledge, telling detail, and deadpan humour.’ — Mark Urban.

STEPHEN G. HYSLOP has written several books on American history, including National Geographic’s Eyewitness to the Civil War and Atlas of the Civil War. A former writer and editor at Time-Life Books, he contributed to many volumes on the Second World War, including Great Photographs of World War II, Lightning War, and s: The main origin of antibiotic resistance, also Origins of resistance to toxic agents book antimicrobial resistance, is their misuse.

As underlined by the European Centre for Disease Prevention and Control (ECDC) they are three main types of misuses (ref 1). Often antibiotics are unnecessarily prescribed for viral infections, against which they have no effect.; When diagnoses are not accurately made and the causative micro. Resistance is the most serious bottleneck in the successful use of pesticides these days.

The intensive use of pesticides has led to the development of resistance in many targeted pest species around the globe (Tabashnik et al., ). Number of resistant insects and mite species had risen to by the end ofand increased to over by. Toxic: A History of Nerve Agents, From Nazi Germany to Putin’s Russia.

Toxic is a comprehensive book covering all of these events. Although it contains some professional reminiscences. These bacterial agents formed in vitro on different bio-materials consist of micro-colonies which are resistant to a range of antibacterial agents, through several mechanisms of resistance [30, 31].

Microorganisms can be organized as biofilms, including pathogens, thus offering a means to protect themselves against antimicrobial agents. These adverse effects can take many forms, ranging from immediate death to subtle changes not appreciated until months or years later. They may occur at various levels within the body, such as an organ, a type of cell, or a specific biochemical.

Our understanding of how toxic agents damage the body has progressed along with medical knowledge. Toxic agent or substance Toxic agent is anything that can produce an adverse biological effect.

It may be chemical, physical, or biological in form. Toxic agents may be: chemical (such as cyanide), physical (such as radiation) and biological (such as snake venom).

Toxic substance is simply a material which has toxic. Chemical warfare was revolutionized by Nazi Germany 's discovery of the nerve agents tabun (in ) and sarin (in ) by Gerhard Schrader, a chemist of IG Farben.

IG Farben was Germany's premier poison gas manufacturer during World War II, so the weaponization of these agents cannot be considered accidental. Resistance induced by the streptococcal preparation, although relatively specific, is directed not only against the streptococcal preparation but also against saponin.

Mice made refractory to the streptococcal preparation and to saponin exhibit normal susceptibility to a number of other toxic agents, with the possible exception of the alpha. On CDC’s website, antibiotic resistance is also referred to as antimicrobial resistance or drug resistance.

Antibiotic resistance has the potential to affect people at any stage of life, as well as the healthcare, veterinary, and agriculture industries, making it one of the world’s most urgent public health problems.

Antibiotic resistance is one of the biggest public health challenges of our time. Each year in the U.S., at least million people get an antibiotic-resistant infection, and more t people die. Fighting this threat is a public health priority that requires a collaborative global approach across sectors.

CDC is working to combat this. The resistance of Chinese hamster epithelial liver cells (CHEL) and Chinese hamster fibroblasts (V79) towards toxic purine analogues has been determined. The liver cells are more sensitive than fibroblasts to 6-thioguanine (6-TG), 8-azaguanine (8-AZ) and 2,6-diaminopurine (DAP).

Resistance can arise due to alteration of the target site for the toxic action. What is the site of the toxic action within the sensitive cell. Why and the infecting agent [1]. Throughout human history, intentional application of poison has been used as a method of murder, pest-control, suicide, and execution.

As a method of execution, poison has been ingested, as the ancient Athenians did (see Socrates), inhaled, as with carbon monoxide or hydrogen cyanide (see gas chamber), or injected (see lethal injection).Poison's lethal effect can be combined with its allegedly. By Kevin E. Noonan -- One of the wonders and satisfactions of modern science has been the elucidation (usually based in genetics) of the wonders of nature that have been famously observed but not explained until the proper tools (again, usually genetic) have been developed.

One of these is the ability of certain animals to grow and thrive on a diet comprising otherwise toxic substances. Key words Antimicrobial agents, Resistant bacteria, History not achieve beneficial effect, and moreover, may lead to a worse prognosis.

In addition, in a situation where multidrug-resistant organisms have spread widely, there may be quite a limited choice of agents for antimicrobial therapy.

At present, fewer brand new antimicrobial agents. Bacteria can gain resistance to toxic levels of Zn, Cd, and Co by developing an effluxbased mechanism to remove a respective element [25, 38].

Cobalt-zinc-cadmium resistance protein (czcA) encodes. Resistance definition is - an act or instance of resisting: opposition. How to use resistance in a sentence. Toxic Agents Atomic Radiation ExposureAgent Orange Exposure Toxic Agents: Atomic Radiation Exposure From toradioactive fallout from U.S.

above‐ground nuclear weapons tests exposed overmilitary personnel, as well as a large but indeterminate number of civilian test workers and and so‐called downwinders, people living near the test sites.

A toxic substance is a substance that can be poisonous or cause health effects. People are generally concerned about chemicals like polychlorinated biphenyls (PCBs) and dioxin which can be found at some hazardous waste sites. Products that we use daily, such as household cleaners, prescription and over-the-counter drugs, gasoline, alcohol.

The Parisiennes who survived told Anne Sebba why history forgot them T he myth of the French Resistance goes something like this. French men, except for a “miserable fistful”, all resisted.

"Evolution in a Toxic World addresses the challenges posed to life on earth by a plethora of toxic threats. There are chapters dedicated to ozone, oxygen, metals, assorted chemical agents, cancer, etc.

The book serves as an excellent introduction to the topic of toxicology and evolution for. Drug resistance, Property of a disease-causing organism that allows it to withstand drug therapy.

In any population of infectious agents, some have a mutation that helps them resist the action of a drug. The drug then kills more of the nonresistant microbes, leaving the mutants without competition to multiply into a resistant strain.

structure of toxic agents, the means of exposure to them, their movement through the body, and their action at the molecular level. Finally, there is a section on the factors that characterize the expression of the toxic effects in the population. The set of classes that describe a toxic agent and its effects include: • Composition • Origin.

It was a painful, horrifying and secret part of America's history during World War II. The U.S. government conducted experiments with mustard. Teaching Tolerance provides free resources to educators—teachers, administrators, counselors and other practitioners—who work with children from kindergarten through high school.

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Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases.

Understanding antibiotic resistance, therefore, is becoming increasingly. Curious, Fleming decided to grow the mold in pure culture, from which he was able to see that colonies of the bacterium Staphylococcus aureus were being destroyed by the mold Penicillium notatum, proving, in principle at least, the existence of an antibacterial g named the substance penicillin and published his findings innoting that his discovery might someday have.

experienced toxic co-workers say they lost time wor-rying about the situation and what might happen in the future. Fifty percent contemplated leaving their jobs after dealing with toxic people, and 12 percent actually did so.

In their study, one respondent told Kusy and Holloway that the toxic person was a senior. Mercuy Toxicity 13 and Bacterial Resistance Mercury is released into the environment as Hg(II) ions through weathering of its most common ore, HgS, red cinnabar. Organomercurials of general formula RHgX used in agriculture have also entered the environment as toxic.

DDT, prepared by the reaction of chloral with chlorobenzene in the presence of sulfuric acid, was first made in ; its insecticidal properties were discovered in by a Swiss chemist, Paul Hermann and after World War II, DDT was found to be effective against lice, fleas, and mosquitoes (the carriers of typhus, of plague, and of malaria and yellow fever, respectively) as.

methicillin resistance to Staphylococcus aureus emerged.9 MRSA strains generally are now resistant to other antimicrobial classes including aminoglycosides, beta-lactams, carbapenems, cephalosporins, fluoroquinolones and macrolides,11 Most of the resistance was secondary to production of beta-lactamase enzymes or intrinsic resistance.Vancomycin became available for clinical use >50 years ago but was soon discarded in favor of other antibiotics that were deemed to be more efficacious and less toxic.

The advent of pseudomembranous enterocolitis, coupled with the spread of methicillin-resistant Staphylococcus aureus, led to a re .Assessment of Toxic Agents at the Workplace: Roles of Ambient and Biological Monitoring th Edition by A. Berlin (Author) ISBN ISBN Why is ISBN important?

ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book.

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